Faculty Directory

Sriram, Ganesh

Sriram, Ganesh

Associate Professor, Keystone Professor
Associate Chair and Undergraduate Program Director
Chemical and Biomolecular Engineering
Maryland Energy Innovation Institute
1208D Chemical and Nuclear Engineering Building

EDUCATION

Ph.D., Iowa State University, 2004

BACKGROUND

Dr. Ganesh Sriram is Keystone Assistant Professor in the Department of Chemical and Biomolecular Engineering and Affiliate Faculty Member in the Bioengineering and Plant Biology graduate programs at University of Maryland. After earning his bachelor's and master's degrees in chemical engineering from Indian Institute of Technology (IIT) Bombay, he graduated a Ph.D. in chemical engineering from Iowa State University in 2004, working in the lab of Dr. Jacqueline Shanks. From 2004 to 2007, he was a postdoctoral researcher in the labs of Dr. Katrina Dipple and Dr. James Liao at UCLA.

HONORS AND AWARDS

  • Keystone Professorship, A. James Clark School of Engineering, University of Maryland, 2011
  • Outstanding Young Engineer Award and Allan C. Davis Medal, Maryland Academy of Sciences and Maryland Science Center, 2011
  • Minta Martin Award, A. James Clark School of Engineering, University of Maryland, 2008
  • Samuel Roberts Noble Foundation Best Presentation Award, Third International Congress on Plant Metabolomics, 2004
  • Metabolic Engineering III Fellowship, Engineering Conferences International, 2000
  • Best Innovative Potential Master’s Thesis Award, Indian National Academy of Engineering, 1999 (Conferred by the Prime Minister of India)
  • Young Scientist Award for Best Research Paper, International Congress for Sustainable Development of Environment, 1997

PROFESSIONAL MEMBERSHIPS

  • Sigma Xi, The Scientific Research Society
  • American Institute of Chemical Engineers
  • American Chemical Society
  • American Society of Plant Biologists

 

Systems biology and metabolic engineering (metabolic networks, regulatory networks, fuel production from biorenewable resources); genetically inherited metabolic disorders.


The Sriram Lab's research is focused on two related areas: metabolic engineering and systems biology, especially of eukaryotes. The group's  specialties are metabolic flux analysis and gene regulatory network analysis. Toward performing such analyses, the group combines experimental methods such as isotope labeling, two-dimensional (2-D) NMR, gas chromatography-mass spectrometry (GC-MS), DNA microarray analysis and quantitative RT-PCR (qPCR) together with computational methods.

For more information, please visit Professor Sriram's web site.

Professor Sriram currently teaches or has taught the following courses:

  • BIOE 120: Biology for Engineers
  • ENCH 215: Chemical Engineering Analysis
  • ENCH 300: Chemical Process Thermodynamics
  • ENCH 468M/BIOE 489L: Metabolic Pathway Engineering

Zheng Y§, Quinn AH§, Sriram G. Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum. Microbial Cell Factories 12: 109. (§These authors contributed equally and are listed in the order in which they joined the project.) View at publisher (OPEN ACCESS)

Misra A, Sriram G. Network component analysis provides quantitative insights on an Arabidopsis transcription factor-gene regulatory network. BMC Systems Biology 7: 126. View at publisher (OPEN ACCESS) (Highly Accessed)

Misra A, Conway MF, Johnnie J, Qureshi TM, Derrick AM, Agbo EC, Sriram G. (2013) Metabolic analyses elucidate nontrivial gene targets for amplifying dihydroartemisinic acid production in yeast. Frontiers in Microbiology, 4: 200. View at publisher (OPEN ACCESS)

Nargund S, Sriram G (2013) Designer labels for plant metabolism: Statistical design of isotope labeling experiments for improved quantification of flux in complex plant metabolic networks. Molecular BioSystems 9: 99-112. View at publisher

Alper HS, Cirino PC, Nevoigt E, Sriram G (2010) Applications of synthetic biology in microbial biotechnology. Journal of Biomedicine and Biotechnology (now BioMed Research International), article ID 918391, 2 pages. Guest editorial (invited but not peer-reviewed). View at publisher (OPEN ACCESS) (non-peer reviewed editorial)

Zheng Y, Sriram G (2010) Mathematical modeling: bridging the gap between concept and realization in synthetic biology. Journal of Biomedicine and Biotechnology (now BioMed Research International) article ID 541609, 16 pages. View at publisher (OPEN ACCESS)

Sriram G, Rahib L, Parr LS, Liao JC, Dipple KM (2010) Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells. Metabolic Engineering 12:332-340. View at publisher View at PMC (OPEN ACCESS)

Rahib L, Sriram G, Harada MK, Liao JC, Dipple KM (2009) Transcriptomic and network component analysis of glycerol kinase in skeletal muscle using a mouse model of glycerol kinase deficiency. Molecular Genetics and Metabolism 96:106-112. View at publisher View at PMC (OPEN ACCESS)

Iyer VV, Sriram G, Fulton DB, Zhou R, Westgate ME, Shanks JV (2008) Metabolic flux maps: An effective tool for studying the effect of temperature on protein and oil biosynthesis in developing soybean cotyledons. Plant, Cell, and Environment 31:506-517. View at publisher (OPEN ACCESS)

Sriram G, Rahib L, He J-S, Campos AE, Liao JC, Dipple KM (2008) Global metabolic changes due to glycerol kinase overexpression in rat liver cells. Molecular Genetics and Metabolism 93:145-159. View at publisher View at PMC (OPEN ACCESS)

Sriram G, Iyer VV, Fulton DB, Shanks JV (2007) Identification of hexose hydrolysis products in metabolic flux analytes: A case study of levulinic acid in plant protein hydrolysate. Metabolic Engineering 9: 442-451. (Cover article) View at publisher

Sriram G, Fulton DB, Shanks JV (2007) Flux quantification in central carbon metabolism of Catharanthus roseus hairy roots by 13C labeling and comprehensive bondomer balancing. Phytochemistry 68: 2243-2257. View at publisher

Sriram G§, González-Rivera O§, Shanks JV (2006) Determination of biomass composition of Catharanthus roseus hairy roots for metabolic flux analysis. Biotechnology Progress 22: 1659-1663. §Equally contributing authors. View at publisher

Sriram G, Martinez JA, McCabe ERB, Liao JC, Dipple KM (2005) Single-gene disorders: What role could moonlighting enzymes play? American Journal of Human Genetics 76: 911-924. View at publisher View at PMC (OPEN ACCESS)

Sriram G, Fulton DB, Iyer VV, Peterson JM, Zhou R, Westgate ME, Spalding MH, Shanks JV (2004) Quantification of compartmented metabolic fluxes in developing soybean embryos by employing biosynthetically directed fractional 13C labeling, two-dimensional [13C, 1H] nuclear magnetic resonance, and comprehensive isotopomer balancing. Plant Physiology 136: 3043-3057. View at publisher (OPEN ACCESS) Featured in Faculty of 1000 Biology

Sriram G, Shanks JV (2004) Improvements in metabolic flux analysis using carbon bond labeling experiments: bondomer balancing and Boolean function mapping. Metabolic Engineering 6: 116-132. View at publisher

Maryland Energy Innovation Institute Awards Three Energy Fellowships

New innovations in sustainable energy storage and generation awarded

ChBE Students Benefit from Co-op Experience

Advised by Ganesh Sriram, six students took a break from their studies to obtain hands-on experience.

UMD Students Encourage Fellow Academics to Get Moving

Joey Hurm and Tanner Pfendner organize calisthenics club to promote fitness, decrease stress. 

Dat Huynh Wins HHMI Fellowship

Funding will support undergraduate's study of altered metabolism in algal-bacterial coculture. 

Boughter, Gastfriend, Piekarz Win 2014 Undergraduate Research Awards

Students recognized for work on metabolic engineering, nanoparticle synthesis.

Gastfriend Named 2015 Goldwater Scholar

National award supports outstanding undergraduates pursuing careers in research.

Klauda, Sriram Promoted

ChBE professors elevated to rank of Associate Professor with tenure.

NSF Graduate Research Fellowship, Honorable Mentions for ChBE Students

Two undergraduates and one graduate student recognized by NSF for research accomplishments.

Boger, Kreeger and Saez Win 2013 Undergraduate Research Awards

Students recognized for work in red blood cell flow, metabolic pathways, and chitosan microparticles.

Sriram Edits New Book on Plant Metabolism

Book explains latest advances in measurements, analyses and simulations.

Alumnus Promotes Do-It-Yourself Solutions for Labs in Developing Nations

Tekla Labs provides free guides for making equipment from locally available materials.

ChBE Undergrads Win Prestigious Industrial Internships from SCI Program

"Exceptional sophomores and juniors" chosen from nationwide field of applicants for $6K-$10K internships.

2012-2013 ChBE Undergraduate Awards

Exceptional students recognized at annual ceremony.

Where Chemical Engineering and Green Thumbs Meet

Dorsey's HHMI Fellowship supports her study of how a potential biofuel crop recycles nitrogen.

Hollinshead Wins Outstanding ASPIRE Student Research Award

Senior recognized for work on metabolic flux analysis.

2011-2012 ChBE Undergraduate Awards

Exceptional students recognized by the Department, Clark School, and professional societies.

Engineering Algae to Produce Biofuel

New Hulka Energy Research Fellow will explore new route to sustainable biofuels.

Gupta, Simons Win Inaugural Undergraduate Research Awards

Students recognized for work in bacterial signaling, metabolic networks.

Conway Wins Poster Award for Work on Carbon Traffic in Yeast

Undergraduate recognized at American Institute of Chemical Engineers' annual meeting.

Sriram Named Keystone Professor

Professor recognized for classroom innovation and dedication to undergraduates.

Au Presents Plenary Talk at NIST SURF Colloquium

Recent graduate studies new ways to improve pharmaceutical quality control.

Sriram Honored as Outstanding Engineer of the Year

Science Center honors metabolic engineering expert, high-profile grant winner who guides successful students.

Sriram Group Member Wins Library Award

Ho-Man Yeung recognized for effective research methods.

Conway Wins HHMI Fellowship

Funding will support undergraduate's research in metabolic engineering.

2010-2011 ChBE Undergraduate Awards

Exceptional students recognized by the Department, Clark School, and professional societies.

Undergraduate Lin Presents at ASPB Conference

Senior invited to present research poster.

$1.9M NSF Grant Enables Enhanced Study of Biomolecular Structures

New high field spectrometer will help solve problems in biology, medicine, biofuels.

Poplar Tree Biofuel Project: Front Page News!

Sriram, Coleman featured in May 3 issue of The Baltimore Sun.

2009-2010 ChBE Undergraduate Awards

Students recognized at annual Clark School event.

Lin Named UMD Undergraduate Researcher of the Year

Junior recognized for her work with Professor Ganesh Sriram.

Biofuel Technologies Featured on CBS News

Segment highlights poplar research, Zymetis' cellulose-digesting bacterium.

A Tree in Your Tank?

$3.2M NSF grant funds effort to transform poplar trees into biofuel.

Lin Wins ASPB SURF Fellowship

Stipend will support study of carbon traffic in plant cells.

ResearchFest 2009 Winners Announced

Nargund, Thomas, and Dowling presentations come out on top.

ChBE Welcomes 3 New Faculty

Klauda, Wang arrive Fall 2007; Sriram Spring 2008.