Faculty Directory

Sriram, Ganesh

Sriram, Ganesh

Associate Professor
Keystone Professor
Associate Chair and Director of Undergraduate Studies
Chemical and Biomolecular Engineering
Maryland Energy Innovation Institute
Brain and Behavior Institute
4418 Stadium Dr. 1208D

Education and Training

  • Ph.D., Iowa State University, 2004
  • Postdoctoral Fellow, University of California, Los Angeles, 2004-2007


Dr. Ganesh Sriram is Associate Professor and Keystone Professor in the Department of Chemical and Biomolecular Engineering at University of Maryland. After earning his bachelor's and master's degrees in chemical engineering from Indian Institute of Technology (IIT) Bombay, he graduated a Ph.D. in chemical engineering from Iowa State University in 2004, working in the lab of Dr. Jacqueline Shanks. From 2004 to 2007, he was a postdoctoral researcher in the labs of Dr. Katrina Dipple and Dr. James Liao at UCLA.

Honors and Awards (Selected)

  • Poole & Kent Teaching Award for Senior Faculty, A. James Clark School of Engineering, University of Maryland, 2022
  • Keystone Professorship, A. James Clark School of Engineering, University of Maryland, 2011
  • Outstanding Young Engineer Award and Allan C. Davis Medal, Maryland Academy of Sciences and Maryland Science Center, 2011
  • Samuel Roberts Noble Foundation Best Presentation Award, Third International Congress on Plant Metabolomics, 2004
  • Metabolic Engineering III Fellowship, Engineering Conferences International, 2000
  • Best Innovative Potential Master’s Thesis Award, Indian National Academy of Engineering, 1999

Professional Memberships

  • American Institute of Chemical Engineers (AIChE)
  • American Chemical Society (ACS)
  • American Society of Plant Biologists (ASPB)
  • American Association for the Advancement of Science (AAAS)
  • Sigma Xi, the Scientific Research Society

  • Metabolic engineering
  • Metabolic networks
  • Flux balance analysis (FBA)
  • Isotope-assisted metabolic flux analysis (iMFA)
  • Regulatory networks
  • Plant metabolism
  • Human metabolism
  • Fuel production from biorenewable resources
  • Metabolic disorders

The Sriram Lab's research is focused on two related areas: metabolic engineering and systems biology, especially of eukaryotes. The group's  specialties are metabolic flux analysis and gene regulatory network analysis. Toward performing such analyses, the group combines experimental methods such as isotope labeling, two-dimensional (2-D) NMR, gas chromatography-mass spectrometry (GC-MS), DNA microarray analysis and quantitative RT-PCR (qPCR) together with computational methods.

Professor Sriram currently teaches or has taught the following courses:

  • BIOE 120: Biology for Engineers
  • CHBE100: Exploring ChBE
  • CHBE101 (previously listed as ENCH215): Introduction to Chemical and Biomolecular Engineering
  • CHBE301 (previously listed as ENCH300): Chemical Process Thermodynamics
  • CHBE444: Process Economics and Design I
  • CHBE484 (also listed as ENCH468M, BIOE 489L, ENCH648M): Metabolic Pathway Engineering

  • Lugar DJ, Sriram G. Isotope-assisted metabolic flux analysis as an equality-constrained nonlinear program for improved scalability and robustness. PLOS Computational Biology. 2022;18: e1009831. doi:10.1371/journal.pcbi.1009831
  • Goldberg DS, Sriram G. Assessment of short and longer-term impacts of a 1-credit chemical engineering first-year seminar. Chemical Engineering Education. 2021 [cited 22 May 2022]. doi:10.18260/2-1-370.660-129531
  • Moiz B, Garcia J, Basehore S, Sun A, Li A, Padmanabhan S, et al. 13C metabolic flux analysis indicates endothelial cells attenuate metabolic perturbations by modulating TCA activity. Metabolites. 2021;11: 226. doi:10.3390/metabo11040226
  • Sittmann J, Bae M, Mevers E, Li M, Quinn A, Sriram G, et al. Bacterial diketopiperazines stimulate diatom growth and lipid accumulation. Plant Physiology. 2021;186: 1159–1170. doi:10.1093/plphys/kiab080
  • Mack SG, Sriram G. NetFlow: A tool for isolating carbon flows in genome-scale metabolic networks. Metabolic Engineering Communications. 2021;12: e00154. doi:10.1016/j.mec.2020.e00154
  • Lugar DJ, Mack SG, Sriram G. NetRed, an algorithm to reduce genome-scale metabolic networks and facilitate the analysis of flux predictions. Metabolic Engineering. 2021;65: 207–222. doi:10.1016/j.ymben.2020.11.003
  • Chung J, Sriram G, Keefer CL. Nanoparticle technology improves in-vitro attachment of cattle (Bos taurus) trophectoderm cells. Biotechnol Lett. 2020;42: 2083–2089. doi:10.1007/s10529-020-02926-w
  • Zhang X, Misra A, Nargund S, Coleman GD, Sriram G. Concurrent isotope-assisted metabolic flux analysis and transcriptome profiling reveal responses of poplar cells to altered nitrogen and carbon supply. Plant J. 2018;93: 472–488. doi:10.1111/tpj.13792
  • Parr LS, Sriram G, Nazarian R, Rahib L, Dipple KM. The ATP-stimulated translocation promoter (ASTP) activity of glycerol kinase plays central role in adipogenesis. Molecular Genetics and Metabolism. 2018;124: 254–265. doi:10.1016/j.ymgme.2018.06.001
  • Ho CK, Sriram G, Dipple KM. Insulin sensitivity predictions in individuals with obesity and type II diabetes mellitus using mathematical model of the insulin signal transduction pathway. Molecular Genetics and Metabolism. 2016;119: 288–292. doi:10/gdq92s
  • Ho CK, Rahib L, Liao JC, Sriram G, Dipple KM. Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data. Molecular Genetics and Metabolism. 2015;114: 66–72. doi:10/gdq92r
  • Islam N, Li G, Garrett WM, Lin R, Sriram G, Cooper B, et al. Proteomics of nitrogen remobilization in poplar bark. J Proteome Res. 2015;14: 1112–1126. doi:10.1021/pr501090p
  • Nargund S, Misra A, Zhang X, Coleman GD, Sriram G. Flux and reflux: Metabolite reflux in plant suspension cells and its implications on isotope-assisted metabolic flux analysis. Mol BioSyst. 2014;10: 1496–1508. doi:10.1039/C3MB70348G
  • Zheng Y, Quinn AH, Sriram G. Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum. Microbial Cell Factories. 2013;12: 109. doi:10.1186/1475-2859-12-109

Do Suddenly Self-Centered Brain Cells Promote Disease?

NSF Award Funds UMD Alzheimer’s Research Into Brain Glucose Metabolism

$7.9 Million in NIH Awards Propel UMD Aging Research

New multidisciplinary collaborations take on challenges like Alzheimer’s disease prevention.

Ganesh Sriram Wins 2022 Poole & Kent Teaching Award for Senior Faculty

Sriram will be honored at the spring commencement ceremony.

ChemE Undergrad Wins 2021 Hollings Scholarship

The award, provided by the National Oceanic and Atmospheric Administration, is granted to outstanding students studying in related mission fields.

ChBE Faculty Members Receive UMD BBI Seed Grants

Srinivasa Raghavan and Ganesh Sriram will work on cross-disciplinary projects.

Maryland Energy Innovation Institute Awards Three Energy Fellowships

New innovations in sustainable energy storage and generation awarded

ChBE Students Benefit from Co-op Experience

Advised by Ganesh Sriram, six students took a break from their studies to obtain hands-on experience.

UMD Students Encourage Fellow Academics to Get Moving

Joey Hurm and Tanner Pfendner organize calisthenics club to promote fitness, decrease stress. 

Dat Huynh Wins HHMI Fellowship

Funding will support undergraduate's study of altered metabolism in algal-bacterial coculture. 

Boughter, Gastfriend, Piekarz Win 2014 Undergraduate Research Awards

Students recognized for work on metabolic engineering, nanoparticle synthesis.

Gastfriend Named 2015 Goldwater Scholar

National award supports outstanding undergraduates pursuing careers in research.

Klauda, Sriram Promoted

ChBE professors elevated to rank of Associate Professor with tenure.

NSF Graduate Research Fellowship, Honorable Mentions for ChBE Students

Two undergraduates and one graduate student recognized by NSF for research accomplishments.

Boger, Kreeger and Saez Win 2013 Undergraduate Research Awards

Students recognized for work in red blood cell flow, metabolic pathways, and chitosan microparticles.

Sriram Edits New Book on Plant Metabolism

Book explains latest advances in measurements, analyses and simulations.

Alumnus Promotes Do-It-Yourself Solutions for Labs in Developing Nations

Tekla Labs provides free guides for making equipment from locally available materials.

ChBE Undergrads Win Prestigious Industrial Internships from SCI Program

"Exceptional sophomores and juniors" chosen from nationwide field of applicants for $6K-$10K internships.

2012-2013 ChBE Undergraduate Awards

Exceptional students recognized at annual ceremony.

Where Chemical Engineering and Green Thumbs Meet

Dorsey's HHMI Fellowship supports her study of how a potential biofuel crop recycles nitrogen.

Hollinshead Wins Outstanding ASPIRE Student Research Award

Senior recognized for work on metabolic flux analysis.

2011-2012 ChBE Undergraduate Awards

Exceptional students recognized by the Department, Clark School, and professional societies.

Engineering Algae to Produce Biofuel

New Hulka Energy Research Fellow will explore new route to sustainable biofuels.

Gupta, Simons Win Inaugural Undergraduate Research Awards

Students recognized for work in bacterial signaling, metabolic networks.

Conway Wins Poster Award for Work on Carbon Traffic in Yeast

Undergraduate recognized at American Institute of Chemical Engineers' annual meeting.

Sriram Named Keystone Professor

Professor recognized for classroom innovation and dedication to undergraduates.

Au Presents Plenary Talk at NIST SURF Colloquium

Recent graduate studies new ways to improve pharmaceutical quality control.

Sriram Honored as Outstanding Engineer of the Year

Science Center honors metabolic engineering expert, high-profile grant winner who guides successful students.

Sriram Group Member Wins Library Award

Ho-Man Yeung recognized for effective research methods.

Conway Wins HHMI Fellowship

Funding will support undergraduate's research in metabolic engineering.

2010-2011 ChBE Undergraduate Awards

Exceptional students recognized by the Department, Clark School, and professional societies.

Undergraduate Lin Presents at ASPB Conference

Senior invited to present research poster.

$1.9M NSF Grant Enables Enhanced Study of Biomolecular Structures

New high field spectrometer will help solve problems in biology, medicine, biofuels.

Poplar Tree Biofuel Project: Front Page News!

Sriram, Coleman featured in May 3 issue of The Baltimore Sun.

2009-2010 ChBE Undergraduate Awards

Students recognized at annual Clark School event.

Lin Named UMD Undergraduate Researcher of the Year

Junior recognized for her work with Professor Ganesh Sriram.

Biofuel Technologies Featured on CBS News

Segment highlights poplar research, Zymetis' cellulose-digesting bacterium.

A Tree in Your Tank?

$3.2M NSF grant funds effort to transform poplar trees into biofuel.

Lin Wins ASPB SURF Fellowship

Stipend will support study of carbon traffic in plant cells.

ResearchFest 2009 Winners Announced

Nargund, Thomas, and Dowling presentations come out on top.

ChBE Welcomes 3 New Faculty

Klauda, Wang arrive Fall 2007; Sriram Spring 2008.