BIOE Seminar: Biodegradable particles for vaccine delivery

Friday, November 18, 2022
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2121
Tao Lowe
taolowe@umd.edu

Aliasger K. Salem
University of Iowa
Associate Vice President for Research at the University of Iowa and Bighley Chair and Professor of Pharmaceutical Sciences at the University of Iowa College of Pharmacy

Biodegradable particles for vaccine delivery

This event will be offered in a hybrid format. Login details will be sent to current BIOE faculty, affiliates, students, postdocs, and those who have previously asked to subscribe to our seminars listserv. If you do not currently receive our weekly seminars emails but you wish to attend this event, please email bioe-comms@umd.edu.

Abstract 

Antigen-loaded or antigen-coated biodegradable particles are capable of being actively taken up by antigen-presenting cells (APCs), and they have shown promising potential in immunotherapy by initiating a strong immunostimulatory cascade that results in potent antigen-specific immune responses against the target antigen. This lecture will show how such particle based carrier systems offer versatility because they can simultaneously co deliver adjuvants with the antigens to enhance APC activation and maturation.

Speaker Bio

Dr. Aliasger Salem is the Bighley Chair and Professor of Pharmaceutical Sciences at the University of Iowa College of Pharmacy. He was educated in applied chemistry at Aston University of Science and Technology, Birmingham, UK (BSc 1998). He received his Ph.D. in pharmacy at the University of Nottingham, UK in 2002. He then received postdoctoral training at Johns Hopkins School of Medicine until 2004. He is an elected fellow of the American Association for Pharmaceutical Scientists, an elected fellow of the American Association for the Advancement of Science and an elected fellow of the American Institute for Medical and Biological Engineering. His research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems, and on the development of vaccines that stimulate potent antigen-specific immune responses. His laboratory applies microfabrication techniques to develop novel drug and gene delivery devices and to optimize control over polymer-cell interactions. His research group is currently exploring the synergistic application of polymer particle technology, oligonucleotides, modified RNA, adenoviruses, and small molecules for generating sustained stronger immune responses against tumors. He has a parallel program in the area of regenerative medicine. He is the author of over 220 peer-reviewed scholarly publications and has published in journals that include Nature Nanotechnology, Nature Materials, Nature Reviews Urology, Science Translational Medicine, Advanced Materials, The AAPS Journal, Bioconjugate Chemistry, Biomaterials, the Proceedings of the National Academy of Sciences, the Journal of Pharmaceutical Sciences, Pharmaceutical Research, the Journal of Controlled Release, and the International Journal of Pharmaceutics. Salem is the Associate Editor for the AAPS Journal and regularly serves on international and national grant review panels for organizations that include the American Cancer Society, the National Institutes for Health, and the Department of Defense: Congressionally Directed Medical Research Programs.

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