ChBE Distinguished Guest Seminar: Joseph M. DeSimone
Tuesday, September 18, 2012
2:00 p.m.-3:00 p.m.
Room 2110 Chemical and Nuclear Engineering Bldg.
301 405 1935
Co-opting Moores Law: The Cost-effective Design of Vaccines and Therapeutics
Joseph M. DeSimone
Departments of Chemistry and Pharmacology
Institute for Advanced Materials
Institute for Nanomedicine
Center for Cancer Nanotechnology Excellence
Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
Department of Chemical and Biomolecular Engineering
North Carolina State University
Memorial Sloan-Kettering Institute for Cancer Research
Memorial Sloan-Kettering Cancer Center
In 1965, Gordon Moore, co-founder of Intel, described the trend that the number of components in integrated circuits had doubled every year since 1958. This trend has continued to today, enabled by advances in photolithography which has taken the minimum feature size of transistors down from about 10 microns in 1970 to 0.045 microns (45 nm) today. In biological terms, this corresponds to going from the size of a red blood cell to the size of a single virus particle! As such, this top-down nano-fabrication technology from the semiconductor industry is, for the first time, in the size range to be relevant for the design of medicines, vaccines and interfacially active Janus particles. This lecture will describe the design, synthesis and efficacy of organic nano- and micro-particles using a top-down nano-fabrication technique we developed called PRINT (Particle Replication in Non-wetting Templates). PRINT is a continuous, roll-to-roll, high resolution molding technique that allows the fabrication of precisely defined micro- and nano-particles in a continuous manner with control over chemical composition, size, shape, deformability and surface chemistry. With these nanotools, we are establishing definitive biodistribution maps to elucidate the interdependent roles that size, shape, deformability and surface chemistry play on particle distribution as a function of different dosage forms (IV, IP, inhaled, subcutaneous, intramuscular, etc). This information is setting the stage for the design of highly effective chemo-therapeutics, respiratory therapeutics and vaccines which will be described.
About the Speaker
Joseph DeSimone is the Chancellors Eminent Professor of Chemistry at the University of North Carolina at Chapel Hill and William R. Kenan Jr. Professor of Chemical Engineering at North Carolina State University. DeSimone is also an Adjunct Member at Memorial Sloan-Kettering Cancer Center in New York. DeSimone has published over 280 scientific articles and has 120 issued patents in his name with over 120 patents pending. DeSimone is an elected member of both the National Academy of Sciences and the National Academy of Engineering as well as the American Academy of Arts and Sciences. DeSimone has received over 40 major awards and recognitions including the 2012 Walston Chubb Award for Innovation by Sigma Xi, 2011 Mendel Medal from Villanova, 2010 AAAS Mentor Award, the 2009 NIH Directors Pioneer Award, the 2009 North Carolina Award, and the 2008 Lemelson-MIT Prize for Invention and Innovation.
DeSimone, an innovative polymer chemist, has made breakthrough contributions in green chemistry, fluoropolymer synthesis, colloid science and nano-biomaterials. He pioneered supercritical CO2-based polymerization reactions and the self-assembly of molecules in compressible media. He has shown the benefit of novel fluoro-elastomers for soft lithographic applications, including the synthesis of shape-controlled nano-biomaterials. DeSimone received his B.S. in Chemistry in 1986 from Ursinus College in Collegeville, Pa. and his Ph.D. in Chemistry in 1990 from Virginia Tech.