ChBE Seminar Series: Zhongjun Jon Wu
Tuesday, February 7, 2012
11:00 a.m.-12:00 p.m.
Room 2110 Chemical and Nuclear Engineering Bldg.
Professor Panagiotis Dimitrakopoulos
Use of Computational Fluid Dynamics in Development of Cardiovascular Medical Devices: From Concept to Clinical Practice
Cardiovascular medical devices have been commonly used to treat various forms of cardiovascular/cardiopulmonary diseases or to replace diseased human organs, enhancing survival for many patients with otherwise hopeless medical conditions. Fluid dynamics in these devices plays the key role in their function and blood biocompatibility. Although current devices are more biocompatible than their forerunners, they still cause blood damage, such as hemolysis, platelet activation, thrombosis and embolization, which may result in serious clinical events and are directly related to fluid dynamics and artificial materials of these devices. Significant research efforts have been devoted to studying the device-blood interactions and minimizing these non-physiological fluid dynamic conditions to improve the functional characteristics and bio/hemo-compatibility of the these medical devices. With the advances in computer technology, computational fluid dynamics (CFD) has been increasingly used in the study of device induced blood damage and the development process of these devices. CFD can provide flow field details in complex geometry and various boundary conditions, which will help to reduce the chances of blood damage caused by these devices. In this talk, an overview of the fundamental technical problems associated with cardiovascular medical devices will be discussed. The use of CFD in the development of the integrated artificial pump-lung technology and circulatory assist devices from the initial concept to clinical practice will be presented.