ChBE Seminar Series: Christopher Roberts
Tuesday, November 22, 2011
11:00 a.m.-12:15 p.m.
Room 2110 Chemical and Nuclear Engineering Bldg.
Professor Panagiotis Dimitrakopoulos
Protein Interactions, Phase Behavior, and Aggregation of Therapeutic Proteins
Department of Chemical Engineering
University of Delaware
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Protein aggregation is a ubiquitous concern during biopharmaceutical product formulation and process development. The presence of even relatively small quantities of soluble or insoluble non-native aggregates may significantly increase product development time and expenses, and cause safety issues. The process of nonnative aggregation has also attracted long-standing interest from a medical perspective due to its potential role in a growing number of chronic diseases such as Huntington's Disease, Alzheimer's Disease, and prion diseases. In both cases, there is evidence that the size, structure, and/or morphology of aggregates are important factors in the biological response(s) to aggregates in vivo. Aggregation of native or folded proteins is also a long-standing area of research, both as a possible separations approach, as well as its implications for limiting drug dosage or delivery options. This seminar focuses on a combination of experimental, modeling, and protein engineering approaches to control or predict the effects of mutations and solvent conditions on aggregation and self-assembly of therapeutic and model proteins.
Seniors and Juniors who are interested in attending the University of Delaware for graduate school are invited to join Professor Roberts to learn more from 1:30 p.m.2:00 p.m. in the ChBE conference room (2113A Chem/Nuc).