ChBE Seminar: Functionalized Surfactant Nanomaterials: Synthesis, Characterization & Applications
Speaker: Philip DeShong, Professor of Chemistry & Biochemistry, UMD
Title: Functionalized Surfactant Nanomaterials: Synthesis, Characterization and Applications to Targeted Drug Delivery and Vaccine Formulation
Catanionic surfactant vesicles (CSVs) are unilamellar vesicles that form spontaneously from mixtures of cationic and anionic surfactants. The resulting CSVs are remarkably robust, even in biological media. The size of the vesicle and its surface charge can be controlled by choice of surfactants, and the external leaflet of the vesicle can be decorated with a variety of biologically relevant materials.
In this seminar, the focus on the discussion will be synthesis and characterization of functionalized CSVs, including (1) the incorporation of a variety of chemotherapeutic agents into the hydrophobic leaflet, and decoration of the outer surface of the leaflet with moieties that can serve as targeting agents. Applications of functionalized CSVs to targeted drug delivery, and vaccine formulation will be addressed.