ChBE Seminar Series: Wilfred Chen
Tuesday, December 6, 2016
Room 2108, Chemical and Nuclear Engineering Building
Gore Professor of Chemical Engineering
University of Delaware
Adding Logic to Complex Protein Functions
Proteins are the most versatile among the various biological building blocks. However, the strength of proteins - their versatility and specific interactions - also complicates and hinders their systematic design and engineering. Our lab has been interested in exploiting the modular nature of protein domains to design synthetic complexes that can perform new biological functions. By adding logical components into the design, protein complexes that are dynamic rather than static in nature can be created to adapt to the constantly changing cellular environments. In this presentation, I will outline several successful examples in connecting exchangeable protein domains for predicative engineering applications in (1) energy substantiality and (2) human health.
More about the speaker:
Professor Wilfred Chen joined the University of Delaware in January 1, 2011 as the Gore Professor of Chemical Engineering. He obtained his B.S. degree from UCLA in 1988 and his Ph.D. from Caltech in 1993, both in Chemical Engineering. After one-year postdoc in Switzerland, he joined UC Riverside in 1994. He was Professor of Chemical and Environmental Engineering and the holder of Presidential Chair until 2010. His research interests are in Synthetic Biology and Protein Engineering. Prof. Chen has published more than 220 journal papers and delivered over 70 invited lectures. He serves on the editorial board for seven scientific publications including Applied and Environmental Microbiology and Biotechnology and Bioengineering. He is a fellow of the American Association for the Advancement of Science (AAAS) and the American Institute for Medical and Biological Engineering (AIMBE).
Prof. Chen has also received several awards, including NSF Career Award, AIChE Food, Pharmaceutical, and Bioengineering Division 15c Plenary Lecture, Biotechnology Progress Award for Excellence in Biological Engineering Publication, and Daniel I.C. Wang Award for Excellence in Biochemical Engineering.