Event
Special ChBE Seminar: Partho Dastidar
Wednesday, November 12, 2014
3:30 p.m.-4:30 p.m.
Room 2113A Chemical and Nuclear Eng. Bldg. (Conf. Room)
Professor Srinivasa Raghavan
sraghava@umd.edu
Supramolecular Gels for Self-Delivery Applications
Partho Dastidar
Professor and Head
Department of Organic Chemistry
Indian Association for the Cultivation of Science (IACS), Kolkata, India
A conventional drug delivery system requires a delivery vehicle that is usually made up of polymer, micelles, vesicles etc. However, cytotoxicity of the vehicle, drug loading into the vehicle and its release into the affected site etc. are some of the major challenges in drug delivery research. A new approach is being proposed wherein a drug molecule is converted into supramolecular gel which can then be applied to the affected site topically (both hydro- and organogels) or subcutaneously (hydrogels) thereby getting rid of the vehicle and delivering the drug itself (self-delivery).
By exploiting the lessons learnt in our decade long endevour in designing supramolecular gelators based on supramolecular synthon rationale, we have recently undertaken an ambitious drug delivery research project that aims at developing drug based supramolecular gelators for self-delivery applications. This talk will highlight our recent efforts in converting non-steroidal-anti-inflammatory-drugs (NSAIDs) into supramolecular gelators and their applications both in vitro and in vivo.
References
- Rajdip Roy, Jolly Deb, Siddhartha Sankar Jana and Parthasarathi Dastidar Chem. Asian J., 2014, DOI:10.1002/asia.201402672, in press
- Rajdip Roy, Jolly Deb, Siddhartha Sankar Jana, and Parthasarathi Dastidar Chem. Eur. J. 2014, in press
- Joydeb Majumder, Jolly Deb, Mahua Rani Das, Siddhartha Sankar Jana and Parthasarathi Dastidara, Chem. Commun., 2014, 50, 1671-1674
- Joydeb Majumder, Mahua Rani Das, Jolly Deb, Siddhartha Sankar Jana and Parthasarathi Dastidara, Langmuir, 2013, 29, 10254-10263
About the Speaker
Parthasarathi Dastidar received his Ph.D. degree from Indian Institute of Science, Bangalore, in 1994. After a few postdoctoral stints in Tel-Aviv (Israel), UNAM (Mexico) and Wayne State University (USA), he joined CSMCRI, Bhavnagar, India, in 1998 as a Scientist and moved to the Dept. of Organic Chemistry, IACS, Kolkata, India, where he is currently Professor and Head of the department. He was an invited JSPS fellow at Osaka University, Japan, during 2004. His research interests include crystal engineering, Low molecular organic gelators (LMOGs), coordination polymers, pharmaceutical co-crystals, drug delivery etc. He also serves as a co-editor of Acta Crystallographica Section E since 2009.
(1) Adarsh, N. N.; Dastidar, P. Chem. Soc. Rev., 2012, 41, 3039–3060.
(2) Dastidar, P. Chem. Soc. Rev., 2008, 37, 2699–2715.
