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Sriram, Ganesh

Sriram, Ganesh
Associate Professor, Keystone Professor
Associate Chair and Undergraduate Program Director
1208D Chemical and Nuclear Engineering Building

News About This Professor


Ph.D., Iowa State University, 2004

Research Interests 

Systems biology and metabolic engineering (metabolic networks, regulatory networks, fuel production from biorenewable resources); genetically inherited metabolic disorders.


Dr. Ganesh Sriram is Associate Professor and Keystone Professor in the Department of Chemical and Biomolecular Engineering and Affiliate Faculty Member in the Bioengineering and Plant Biology graduate programs at University of Maryland. After earning his bachelor's and master's degrees in chemical engineering from Indian Institute of Technology (IIT) Bombay, he graduated a Ph.D. in chemical engineering from Iowa State University in 2004, working in the lab of Dr. Jacqueline Shanks. From 2004 to 2007, he was a postdoctoral researcher in the labs of Dr. Katrina Dipple and Dr. James Liao at UCLA.

Current Research Projects 

The Sriram Lab's research is focused on two related areas: metabolic engineering and systems biology, especially of eukaryotes. The group's  specialties are metabolic flux analysis and gene regulatory network analysis. Toward performing such analyses, the group combines experimental methods such as isotope labeling, two-dimensional (2-D) NMR, gas chromatography-mass spectrometry (GC-MS), DNA microarray analysis and quantitative RT-PCR (qPCR) together with computational methods.

For more information, please visit Professor Sriram's web site.


Professor Sriram currently teaches or has taught the following courses:

  • BIOE 120: Biology for Engineers
  • ENCH 215: Chemical Engineering Analysis
  • ENCH 300: Chemical Process Thermodynamics
  • ENCH 468M/BIOE 489L: Metabolic Pathway Engineering

Honors and Awards 

  • Keystone Professorship, A. James Clark School of Engineering, University of Maryland, 2011
  • Outstanding Young Engineer Award and Allan C. Davis Medal, Maryland Academy of Sciences and Maryland Science Center, 2011
  • Minta Martin Award, A. James Clark School of Engineering, University of Maryland, 2008
  • Samuel Roberts Noble Foundation Best Presentation Award, Third International Congress on Plant Metabolomics, 2004
  • Metabolic Engineering III Fellowship, Engineering Conferences International, 2000
  • Best Innovative Potential Master’s Thesis Award, Indian National Academy of Engineering, 1999 (Conferred by the Prime Minister of India)
  • Young Scientist Award for Best Research Paper, International Congress for Sustainable Development of Environment, 1997

Professional Memberships 

  • Sigma Xi, The Scientific Research Society
  • American Institute of Chemical Engineers
  • American Chemical Society
  • American Society of Plant Biologists

Books and Chapters 

Sriram G (ed). (2014) Plant Metabolism: Methods and Protocols. Methods in Molecular Biology, Vol. 1083, 300 pp. Humana Press, New York, NY. ISBN: 978-1-62703-660-3 View at publisher View chapters at publisher

Simons M, Misra A, Sriram G (2014) Genome-scale models of plant metabolism. In: Sriram G, editor. Plant Metabolism. Methods in Molecular Biology. Humana Press. pp. 213–230. View at publisher

Nargund S, Sriram G (2014) Mathematical modeling of isotope labeling experiments for metabolic flux analysis. In: Sriram G, editor. Plant Metabolism. Methods in Molecular Biology. Humana Press. pp. 109–131. View at publisher

Zheng Y, Sriram G (2014) Steady-state and instationary modeling of proteinogenic and free amino acid isotopomers for flux quantification. In: Dieuaide-Noubhani M, Alonso AP, editors. Plant Metabolic Flux Analysis. Methods in Molecular Biology. Humana Press. pp. 155–179. View at publisher

Nargund S§, Joffe ME§, Tran D, Tugarinov V, Sriram G (2013) Nuclear magnetic resonance methods for metabolic fluxomics. In: Alper HS (ed), Systems Metabolic Engineering. Methods in Molecular Biology, 985: 335–351, Humana Press, New York, NY. §Equally contributing authors. View at publisher

Selected Publications 

Zheng Y§, Quinn AH§, Sriram G. Experimental evidence and isotopomer analysis of mixotrophic glucose metabolism in the marine diatom Phaeodactylum tricornutum. Microbial Cell Factories 12: 109. (§These authors contributed equally and are listed in the order in which they joined the project.) View at publisher (OPEN ACCESS)

Misra A, Sriram G. Network component analysis provides quantitative insights on an Arabidopsis transcription factor-gene regulatory network. BMC Systems Biology 7: 126. View at publisher (OPEN ACCESS) (Highly Accessed)

Misra A, Conway MF, Johnnie J, Qureshi TM, Derrick AM, Agbo EC, Sriram G. (2013) Metabolic analyses elucidate nontrivial gene targets for amplifying dihydroartemisinic acid production in yeast. Frontiers in Microbiology, 4: 200. View at publisher (OPEN ACCESS)

Nargund S, Sriram G (2013) Designer labels for plant metabolism: Statistical design of isotope labeling experiments for improved quantification of flux in complex plant metabolic networks. Molecular BioSystems 9: 99-112. View at publisher

Alper HS, Cirino PC, Nevoigt E, Sriram G (2010) Applications of synthetic biology in microbial biotechnology. Journal of Biomedicine and Biotechnology (now BioMed Research International), article ID 918391, 2 pages. Guest editorial (invited but not peer-reviewed). View at publisher (OPEN ACCESS) (non-peer reviewed editorial)

Zheng Y, Sriram G (2010) Mathematical modeling: bridging the gap between concept and realization in synthetic biology. Journal of Biomedicine and Biotechnology (now BioMed Research International) article ID 541609, 16 pages. View at publisher (OPEN ACCESS)

Sriram G, Rahib L, Parr LS, Liao JC, Dipple KM (2010) Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells. Metabolic Engineering 12:332-340. View at publisher View at PMC (OPEN ACCESS)

Rahib L, Sriram G, Harada MK, Liao JC, Dipple KM (2009) Transcriptomic and network component analysis of glycerol kinase in skeletal muscle using a mouse model of glycerol kinase deficiency. Molecular Genetics and Metabolism 96:106-112. View at publisher View at PMC (OPEN ACCESS)

Iyer VV, Sriram G, Fulton DB, Zhou R, Westgate ME, Shanks JV (2008) Metabolic flux maps: An effective tool for studying the effect of temperature on protein and oil biosynthesis in developing soybean cotyledons. Plant, Cell, and Environment 31:506-517. View at publisher (OPEN ACCESS)

Sriram G, Rahib L, He J-S, Campos AE, Liao JC, Dipple KM (2008) Global metabolic changes due to glycerol kinase overexpression in rat liver cells. Molecular Genetics and Metabolism 93:145-159. View at publisher View at PMC (OPEN ACCESS)

Sriram G, Iyer VV, Fulton DB, Shanks JV (2007) Identification of hexose hydrolysis products in metabolic flux analytes: A case study of levulinic acid in plant protein hydrolysate. Metabolic Engineering 9: 442-451. (Cover article) View at publisher

Sriram G, Fulton DB, Shanks JV (2007) Flux quantification in central carbon metabolism of Catharanthus roseus hairy roots by 13C labeling and comprehensive bondomer balancing. Phytochemistry 68: 2243-2257. View at publisher

Sriram G§, González-Rivera O§, Shanks JV (2006) Determination of biomass composition of Catharanthus roseus hairy roots for metabolic flux analysis. Biotechnology Progress 22: 1659-1663. §Equally contributing authors. View at publisher

Sriram G, Martinez JA, McCabe ERB, Liao JC, Dipple KM (2005) Single-gene disorders: What role could moonlighting enzymes play? American Journal of Human Genetics 76: 911-924. View at publisher View at PMC (OPEN ACCESS)

Sriram G, Fulton DB, Iyer VV, Peterson JM, Zhou R, Westgate ME, Spalding MH, Shanks JV (2004) Quantification of compartmented metabolic fluxes in developing soybean embryos by employing biosynthetically directed fractional 13C labeling, two-dimensional [13C, 1H] nuclear magnetic resonance, and comprehensive isotopomer balancing. Plant Physiology 136: 3043-3057. View at publisher (OPEN ACCESS) Featured in Faculty of 1000 Biology

Sriram G, Shanks JV (2004) Improvements in metabolic flux analysis using carbon bond labeling experiments: bondomer balancing and Boolean function mapping. Metabolic Engineering 6: 116-132. View at publisher

Related News 

Dat Huynh Wins HHMI Fellowship
Funding will support undergraduate's study of altered metabolism in algal-bacterial coculture.  August 24, 2017

Boughter, Gastfriend, Piekarz Win 2014 Undergraduate Research Awards
Students recognized for work on metabolic engineering, nanoparticle synthesis. May 8, 2015

Gastfriend Named 2015 Goldwater Scholar
National award supports outstanding undergraduates pursuing careers in research. April 3, 2015

Klauda, Sriram Promoted
ChBE professors elevated to rank of Associate Professor with tenure. June 2, 2014

NSF Graduate Research Fellowship, Honorable Mentions for ChBE Students
Two undergraduates and one graduate student recognized by NSF for research accomplishments. April 16, 2014

Boger, Kreeger and Saez Win 2013 Undergraduate Research Awards
Students recognized for work in red blood cell flow, metabolic pathways, and chitosan microparticles. April 7, 2014

Sriram Edits New Book on Plant Metabolism
Book explains latest advances in measurements, analyses and simulations. January 30, 2014

Alumnus Promotes Do-It-Yourself Solutions for Labs in Developing Nations
Tekla Labs provides free guides for making equipment from locally available materials. September 22, 2013

ChBE Undergrads Win Prestigious Industrial Internships from SCI Program
"Exceptional sophomores and juniors" chosen from nationwide field of applicants for $6K-$10K internships. April 16, 2013

2012-2013 ChBE Undergraduate Awards
Exceptional students recognized at annual ceremony. April 10, 2013

Where Chemical Engineering and Green Thumbs Meet
Dorsey's HHMI Fellowship supports her study of how a potential biofuel crop recycles nitrogen. February 11, 2013

Hollinshead Wins Outstanding ASPIRE Student Research Award
Senior recognized for work on metabolic flux analysis. April 20, 2012

2011-2012 ChBE Undergraduate Awards
Exceptional students recognized by the Department, Clark School, and professional societies. April 20, 2012

Engineering Algae to Produce Biofuel
New Hulka Energy Research Fellow will explore new route to sustainable biofuels. March 2, 2012

Gupta, Simons Win Inaugural Undergraduate Research Awards
Students recognized for work in bacterial signaling, metabolic networks. January 10, 2012

Conway Wins Poster Award for Work on Carbon Traffic in Yeast
Undergraduate recognized at American Institute of Chemical Engineers' annual meeting. November 3, 2011

Sriram Named Keystone Professor
Professor recognized for classroom innovation and dedication to undergraduates. September 1, 2011

Au Presents Plenary Talk at NIST SURF Colloquium
Recent graduate studies new ways to improve pharmaceutical quality control. August 11, 2011

Sriram Honored as Outstanding Engineer of the Year
Science Center honors metabolic engineering expert, high-profile grant winner who guides successful students. May 16, 2011

Sriram Group Member Wins Library Award
Ho-Man Yeung recognized for effective research methods. April 28, 2011

Conway Wins HHMI Fellowship
Funding will support undergraduate's research in metabolic engineering. April 27, 2011

2010-2011 ChBE Undergraduate Awards
Exceptional students recognized by the Department, Clark School, and professional societies. April 19, 2011

Undergraduate Lin Presents at ASPB Conference
Senior invited to present research poster. September 21, 2010

$1.9M NSF Grant Enables Enhanced Study of Biomolecular Structures
New high field spectrometer will help solve problems in biology, medicine, biofuels. August 27, 2010

Poplar Tree Biofuel Project: Front Page News!
Sriram, Coleman featured in May 3 issue of The Baltimore Sun. May 4, 2010

2009-2010 ChBE Undergraduate Awards
Students recognized at annual Clark School event. April 26, 2010

Lin Named UMD Undergraduate Researcher of the Year
Junior recognized for her work with Professor Ganesh Sriram. April 22, 2010

Biofuel Technologies Featured on CBS News
Segment highlights poplar research, Zymetis' cellulose-digesting bacterium. April 21, 2010

A Tree in Your Tank?
$3.2M NSF grant funds effort to transform poplar trees into biofuel. February 25, 2010

Lin Wins ASPB SURF Fellowship
Stipend will support study of carbon traffic in plant cells. April 5, 2009

ResearchFest 2009 Winners Announced
Nargund, Thomas, and Dowling presentations come out on top. February 11, 2009

ChBE Welcomes 3 New Faculty
Klauda, Wang arrive Fall 2007; Sriram Spring 2008. August 28, 2007