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Metabolic Engineering Laboratory

Principal Investigator: 
2209 Chemical and Nuclear Engineering Building

The Metabolic Engineering Laboratory works in the areas of metabolic engineering and systems biology, especially of eukaryotes. Its specialties are metabolic flux analysis and gene regulatory network analysis. Toward performing such analyses, the Sriram Group combines experimental methods such as isotope labeling, two-dimensional (2-D) NMR, gas chromatography-mass spectrometry (GC-MS), DNA microarray analysis and quantitative RT-PCR (qPCR) together with computational methods. Many potential applications of this work focus on plants, the source of commodities such as food, fiber, biofuels, therapeutics, and renewable chemical industry feedstocks. The group's quantitative studies open up the prospect of smartly engineering plants' metabolic networks for beneficial purposes, and therefore hold promise for a sustainable future.